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Kassim Traore

Associate Professor/Chairperson, Pharmacy

Kassim Traore
Office: 128 Pharmacy Building
Address: Campus Box 252
(252) 335-3641
Fax: (252) 335-3508
ktraore@ecsu.edu
Web:

Biography:
Dr. Traore is an associate professor at the Department of Pharmacy and Health Professions

Research Interests: Dr. Traore's work is in the area of redox regulation of gene expression during aging, inflammation, and interactions of environmental chemicals with various cell types. Oxidative stress is a key factor of many human diseases and contributes to the toxicity associated with a number of environmental and therapeutic agents. Although, all macromolecules can be targets of oxidative damage, the oxidation of specific cysteine thiols in some proteins (such as transcription factors, kinases and phosphatases) can have dramatic functional consequences. Many phosphatases are redox-sensitive proteins and their activities are regulated by oxidation of specific cysteine residues in proteins, providing a means of control by oxidative signals. The major goal of my research is to define the role redox-signaling in the mechanism of regulator of gene expression in response to environmental and therapeutic agents.

Education:

BS. Animal Science Technology, RURAL POLYTECHNIC INSTITUTE, Mali (1988). Ph.D. Biochemistry and Molecular Biology, HOWARD UNIVERSITY, USA ( 2002). Postdoctoral Fellow –Toxicology: JOHNS HOPKINS UNIVERSITY, MD (2002-2007).

Selected Publications:

1. Liang Zhou, Matthew C. Beattie Chieh-Yin Lin June Liu, Kassim Traore, Vassilios Papadopoulosc Barry R. Zirkin, Haolin Chen Oxidative Stress and Phthalate-Induced Down-Regulation of Steroidogenesis in MA-10 Leydig Cells Reproductive Toxicology, In Press, Accepted Manuscript, Available online 19 August 2013

2. Traore K, Zirkin B, Thimmulappa RK, Biswal S, Trush MA. Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA. ISRN Oncol. 2012;2012:641246.

3. Fan J, Traore K, Li W, Amri H, Huang H, Wu C, Chen H, Zirkin B, Papadopoulos V. Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells. Endocrinology. 2010 Jul;151(7):3348-62. Epub 2010 May 12.

4. Kassim Traore, Rajni Sharma, Rajesh K Thimmulappa, Walter H. Watson, Shyam Biswal, and Michael A. Trush. Regulation of Erk1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells. Journal of Cellular Physiology, 2008 Jul; 216(1): 276-85..

5. Kassim Traore, Rajni B. Sharma, C. Lynne Burek and Michael A. Trush. Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line. Journal of Cellular Biochemistry. 2007 Mar 1;100 (4):1010-21.

6. Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore Kassim Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Preclinical Evaluation of Targeting the Nrf2 Pathway by Triterpenoids (CDDO-Im and CDDO-Me) for Protection from LPS-Induced Inflammatory Response and Reactive Oxygen Species in Human Peripheral Blood Mononuclear Cells and Neutrophils. Antioxid Redox Signal. 2007 Nov;9(11):1963-70.

7. Rajesh K Thimmulappa; Catherine Scollick; Kassim Traore; Melinda Yates; Michael A Trush; Karen T Liby; Michael B Sporn; Masayuki Yamamoto; Thomas W Kensler; Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications, 2006 Dec 29;351(4):883-9

8. Kassim Traore, Michael A. Trush, Matthew George, Jr., Ernst Wm. Spannhake, Winston Anderson, and Amha Asseffa. Signal Transduction of Phorbol 12-Myristate 13-Acetate (PMA)-induced Growth Inhibition of Human Monocytic Leukemia THP-1 Cells is Reactive Oxygen Dependent". Leukemia Research Journal 2005 Aug; 29(8): 863-879



Degrees:
PhD, Howard University (1998-2002)