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Dolapo Adedeji

Assistant Professor, Pharmacy

Dolapo Adedeji
Office: 329 Pharmacy Building
Address: Campus Box 973
(252) 335-8726
Fax: (252) 335-3158
daadedeji@ecsu.edu
Web:

Biography:
Qualifications

Ph.D. (Chemistry with concentration in Biochemistry), Auburn University, Auburn. Alabama

B.Sc. (Chemical Sciences), University of Agriculture, Abeokuta, Ogun State. Nigeria.

Dr. Dolapo Adedeji is an assistant professor in the department of Pharmacy and Health Professions. She also serves as the program coordinator for the Bachelor of Science in Pharmaceutical Sciences (BSPS)program.

Research Interest

Dr. Dolapo Adedeji's research interests include the development of anti-infective drugs that can be used in the treatment of the diseases caused by bacterial infections and malaria (pathogenic organisms). The rapidly increasing resistance developed by many pathogenic organisms to most of the currently available drugs is posing a serious health concern. There is a need for the development of new drugs for the treatment of the diseases caused by these pathogens. This should exploit target mechanisms that are different from commercial drugs that are currently available. It is important to understand the operation of the metabolic pathways that exist in these pathogens so as to find the appropriate target that can be used in the development of drugs against them. One of such pathways is the 1-deoxy-D-xylulose-5-phosphate (DOXP) for isoprene biosynthesis. This is a new and unique target for the development of anti-infective drugs.

Also working on development of potential anti-cancer drugs for prostate cancer. This is in collaboration with Dr. Innocent Ononiwu, of the Pharmacy department.

Dissertations and Scientific Publications

Ph.D dissertation – Isoprenoid synthesis: New roles for iron-sulfur Clusters

B.Sc dissertation – Earthworm as bio-indicator of metal pollution in Abeokuta City

Yakini Brandy, Innocent Ononiwu, Dolapo Adedeji, Vonetta Williams, Claudia Mouamba, Yasmine Kanaan, Robert L. Copeland, Jr., Dwayne A. Wright, Ray J. Butcher, Samuel R. Denmeade and Oladapo Bakare; “ Synthesis and Cytotoxic Activities of Some 2-Arylnaphtho[2,3-d]oxazole-4,9-dione Derivatives on Androgen-dependent (LNCap) and Androgen-independent (PC3) Human Prostate Cancer Cell Lines”. Invest New Drugs, January 18, 2011. DOI IO.1007/s10637-011-9635-3

Xu, Weiya; Lees, Nicholas; Adedeji, Dolapo; Wiesner, Jochen; Jomaa, Hassan; Hoffman, Brian; Duin, Evert; “ Paramagnetic Species Detected in (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) under steady state and pre-steady state conditions”. Journal of American Chemical Society (2010) 131 (41) 14509 -14520.

Dolapo Adedeji, Heather Hernandez, Jochen Wiesner, Uwe Kohler, Hasan Jomaa, Evert C. Duin, “Possible direct involvement of the active–site [4Fe-4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP”, FEBS Letters 581 (2007) 279-283.

Dolapo Adedeji, Jochen Wiesner, Hasan Jomaa, Evert C. Duin, “Spectroscopic Investigations of GcpE protein”, abstract submitted for 231st American Chemical Society National Meeting and Exposition program, (March 26-30, 2006. Atlanta, GA)

Evert C. Duin, Dolapo Adedeji, Jochen Wiesner, Hasan Jomaa, “Iron-sulfur proteins in the alternative pathway of Isoprene synthesis as novel targets for anti-infective drug development”, abstract submitted for 231st American Chemical Society National Meeting and Exposition program, (March 26-30, 2006. Atlanta, GA)









Degrees:
PhD, Auburn University (2003-2007)